I've worn Woxers for several years now, which I think is a huge boxer brand for AFAB people, so I'm going to relate Knockers to them for anyone here that wears Woxers.
The Knoxers are great 💖 I ended up cutting the gusset out of mine just because I've worn Woxers for several years and hate the feel of a gusset now (not a huge deal! It's easy to trim it out because of the separate seam). The fabric is not too rough, and I appreciate that it isn't mostly spandex. Woxers tends to form to the shape of your body, so it's nice that Knoxers are more free-form. The waistband is definitely more forgiving than the ones on Woxers. It's thicker, but it's also, once again, not squeezing you to death because there isn't a significant amount of spandex. The buttons are not noticeable sensory-wise. The only sensory issue I have is the seam being inward-facing. It can be more noticeable depending on what size of boxer you pick and what you wear it underneath. I'm not sure if this is an easy fix or not, but it's the only thing I would recommend changing. Otherwise, I actually enjoy them more than Woxers!